![]() ![]() Enhancement of slow-wave sleep is intriguing, since reductions in slow-wave sleep have frequently been reported in fibromyalgia and general anxiety disorder. Pregabalin appears to have an effect on sleep and sleep architecture that distinguishes it from benzodiazepines. Leeds Sleep Evaluation Questionnaire ratings of the ease of getting to sleep and the perceived quality of sleep were significantly improved following both active treatments, and ratings of behavior following awakening were significantly impaired by both drug treatments. Pregabalin also significantly reduced the number of awakenings of more than 1 minute in duration. Although there were no differences between the active treatments, both pregabalin and alprazolam reduced rapid eye movement sleep as a proportion of the total sleep period compared with placebo. ![]() Rapid eye movement sleep latency after pregabalin was no different than placebo but was significantly shorter than that found with alprazolam. Pregabalin and alprazolam produced modest, but significant, reductions in sleep-onset latency compared with placebo. Alprazolam significantly reduced slow-wave sleep. Compared with placebo, pregabalin significantly increased slow-wave sleep both as a proportion of the total sleep period and the duration of stage 4 sleep. Objective sleep was measured by an 8-channel polysomnograph subjective sleep was measured using the Leeds Sleep Evaluation Questionnaire. Healthy adult (12 men) volunteers (N=24) received oral pregabalin 150 mg t.i.d., alprazolam 1 mg t.i.d., and placebo t.i.d. Randomized, double-blind, placebo- and active-controlled, 3-way crossover. These stages are determined based on an analysis of brain activity during sleep, which shows distinct patterns that characterize each stage. To assess the effects of pregabalin compared with alprazolam and placebo on aspects of sleep in healthy volunteers. What Are the Sleep Stages in a Normal Sleep Cycle There are four sleep stages, including one for rapid eye movement (REM) sleep and three that form non-REM (NREM) sleep. ![]()
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